8:50 am Chair’s Opening Remarks
Advancing the Next-Generation of Cell-Based Immunotherapies
9:00 am Pharma Leaders Fireside Chat
Synopsis
- Highlighting the synergies between cell-based therapies and vaccines to create a common framework for development
- Sharing thoughts on how the intrinsic service component in the commercialisation of neoantigen therapies requires similar patient preparation, additional treatment, follow up, and a specialised workforce and how these fit into the ‘big pharma’ model
- Identifying opportunities for shared collaboration across different pipelines and creating an outline to develop pipelines with a common thread across the industry to facilitate collaborations, mergers, and acquisitions
9:30 am Developing Multi-Specific Autologous T Cell Therapy Targeting Tumour Neoantigens
Synopsis
- Understanding pokeAcell’s ImmPACT technology – Simple expansion of neoantigen-specific T cells directly from blood
- Exploring how AI-predicted neoantigens are utilised to generate a multi-specific polyclonal functional T cell product
10:00 am Morning Refreshments & StructuredNetworking
Pioneering Dark Antigens for a Brighter Future
11:00 am Shining a Light on Dark Antigens & T Cell Biology to Treat a Broad Patient Population
Synopsis
- Exploring the hidden depths of cancer and T cell biology to discover and characterise unconventional immunotherapy targets
- Looking beyond the known proteome into the genomic dark matter to identify and characterise Dark Antigens uniquely presented on the surface of cancer cells by MHC receptors
- Discussing the role of cloud-based technology to speed up the discovery and assessment process of candidate antigens
11:30 am Targeting a Novel Shared Tumour-Specific Antigen with T Cell Receptor Transduced T Cells for the Treatment of Cancer
Synopsis
- Utilising transgenic T cell receptor (TCR)-based T cell therapies which are powerful to target TSAs
- Representing tumour organoids as reliable and more physiologically relevant models to characterise TSA-specific TCRs in comparison to 2D established tumour cell lines
12:00 pm ERAP1 Inhibition to Generate Neoantigens & Drive Anti-Tumour Cell Killing
Synopsis
- Targeting the endoplasmic reticulum in the antigen presentation pathway to create novel neoantigens in cancer
- Increasing tumour visibility and extending the therapeutic benefit of immunotherapy to many more cancer patients
- Presenting Grey Wolf’s 1st in class ERAP1 inhibitor as a therapeutic pipeline for opportunities
12:30 pm Lunch & Networking
Utilising Neoantigens for Antibody Targeting of Tumours
1:30 pm Antibody-Targeting of Tumour-Associated Carbohydrate Antigens (TACAs) for Passive Immunotherapies
Synopsis
- Presenting TACAs as a novel class of targets exclusively expressed on tumour cells
- Uncovering how TACAs drive tumour progression by mediating metastasis, induction of angiogenesis or down-modulation of the immune system and therefore are ideal targets to interfere with tumour progression and targeting for antibody-mediated cell killing
- Outlining Tacalyx’s technology which allows the generation and characterisation of specific antibodies suitable for clinical development
2:00 pm Targeting Tumour Neoepitopes with Monoclonal Antibodies
Synopsis
- Employing a unique cancer vaccine platform to develop monoclonal antibodies against functional tumour neo-antigens
- Utilising innovative technologies and expertise in immunology, in addition to unique antibody display platforms with an automated high throughput screening
- Using these antibodies to identify the precise neoantigen targeted
2:30 pm Afternoon Refreshments & Structured Networking
Evaluating Combination Therapies to Maximise Anti-Tumour Immune Activity
3:00 pm Dendritic Cells & Their Role in Immunotherapy
Synopsis
• Presenting a new class of cancer vaccine based on an off-the-shelf Antigen Presenting Cell line (PDC*line)
• Discussing a new potent and scalable therapeutic cancer vaccine based on a proprietary allogeneic cell line of Plasmacytoid Dendritic Cells
• Understanding how the PDC*line is much more potent to prime and boost antitumour antigen, including neoantigens, specific cytotoxic T cells than conventional vaccines and improves the response to checkpoint inhibitors
3:30 pm Clinical Combination Strategies with Oncolytic Vaccines in Solid Tumours
Synopsis
• Harnessing the clinical activity of oncolytic adenoviral vector ONCOS-102 in solid tumours of different origin
• Identifying strong and consistent patterns of immuno-modulation with both PD1 blockade and chemotherapy
• Utilising the selection of future combination strategies based on tumour biopsy translational data
4:00 pm Panel Discussion – Evaluating Combination Therapies to Maximise Anti-Tumour Immune Activity
Synopsis
• What is the ideal combination strategy for neoantigen vaccines?
• What are the best combination therapies that maximise T cell responses and efficacy?
• How to identify a clear biologic effect caused by combination
• Improving clinical efficacy through immunotherapy combinations